2001•Bulletin of Chinese CancerRequires access

Evaluation of Segregation Ratio and Hereditability of Gastric Cancer in Taixing County

Suping Li

Abstract

A genetic epidemiologic case-control study with 297 pedigrees (79 genealogies and 198 controls) was carried out to estimate the segregation ratio and hereditability (h2) of gastric cancer by the methods of Li-Mantel-Gart and Falconer.The results showed that the segregation ratio of gastric cancer was 0.1206,significantly less than 0.25,and the genetic model belonged to polygenetics.The h2 of gastric cancer was 21.42%,with 18.23% for male and 31.53% for female.It is indicated that genetic factor is one of the risks for gastric cancer,but it is not a main risk for high incidence of gastric cancer in Taixing County.

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Key concepts: Cancer, Medicine, Internal medicine, Incidence (geometry), Pedigree chart, Cancer incidence, Gastroenterology, Oncology