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The clinical significance of HbA1c in screening of gestational diabetes mellitus

LI Haichua

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Abstract

Objective To evaluate the application probability of glycosylated hemoglobin A1c(HbA1c) in the screening of gestational diabetes mellitus(GDM).Methods 474 pregnant women during pregnant 24-28 weeks were classified into GDM group(30 cases) and non-GDM group(444 cases) according to American Diabetes Association(ADA) guidelines,and they had 75 g oral glucose tolerance test(OGTT) and HbA1c measurement.The results of HbA1c tests between GDM and non-GDM pregnant women were analyzed.Results HbA1c level in GDM group was higher than that in non-GDM group(P0.01).The area under receiver operating characteristic(ROC) curve was 0.969.When the cut-off value was 5.4%,the results showed sensitivity 73.0% and specificity 98.4%.The positive predictive value was 75.9%,and the reliability was 98.2%.Conclusions HbA1c is a promising indicator for detecting GDM.

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What this paper is about

Objective To evaluate the application probability of glycosylated hemoglobin A1c(HbA1c) in the screening of gestational diabetes mellitus(GDM).Methods 474 pregnant women during pregnant 24-28 weeks were classified into GDM group(30 cases) and non-GDM group(444 cases) according to American Diabetes Association(ADA) guidelines,and they had 75 g oral glucose tolerance test(OGTT) and HbA1c measurement.The results of HbA1c tests between GDM and non-GDM pregnant women were analyzed.Results HbA1c level in GDM group was higher than that in non-GDM group(P0.01).The area under receiver operating characteristic(ROC) curve was 0.969.When the cut-off value was 5.4%,the results showed sensitivity 73.0% and specificity 98.4%.The positive predictive value was 75.9%,and the reliability was 98.2%.Conclusions HbA1c is a promising indicator for detecting GDM.

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Available abstract

Objective To evaluate the application probability of glycosylated hemoglobin A1c(HbA1c) in the screening of gestational diabetes mellitus(GDM).Methods 474 pregnant women during pregnant 24-28 weeks were classified into GDM group(30 cases) and non-GDM group(444 cases) according to American Diabetes Association(ADA) guidelines,and they had 75 g oral glucose tolerance test(OGTT) and HbA1c measurement.The results of HbA1c tests between GDM and non-GDM pregnant women were analyzed.Results HbA1c level in GDM group was higher than that in non-GDM group(P0.01).The area under receiver operating characteristic(ROC) curve was 0.969.When the cut-off value was 5.4%,the results showed sensitivity 73.0% and specificity 98.4%.The positive predictive value was 75.9%,and the reliability was 98.2%.Conclusions HbA1c is a promising indicator for detecting GDM.

Key concepts: Gestational diabetes, Medicine, Obstetrics, Diabetes mellitus, Receiver operating characteristic, Hemoglobin, Glucose tolerance test, Pregnancy

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