Distribution and drug resistance of pathogens isolated from hematology department

OBJECTIVE To investigate the clinical distribution characteristics and drug resistance of pathogens in hematology department during the recent two years,and to instruct reasonable clinical application of antibiotics.METHODS The distribution,category and drug resistance of pathogenic bacteria isolated from 2707 specimens of patients in hematology department from Jan.2009 to Nov.2010 were retrospectively analyzed.RESULTS A total of 205 strains of pathogens were isolated.The component ratio of gram-positive bacteria,gram-negative bacteria and fungi were 24.39%,50.07% and 18.54%,respectively.The most common gram-negative bacteria were Escherichia coli,Pseudomonas aeruginosa,and Klebsiella pneumonia;and the dominant gram-positive pathogenic bacteria were coagulase-negative Staphylococcus and Staphylococcus aureus;and the major fungi were Candida albicans and Candida parapsilosis.The dominant source of pathogens was blood(83.71%),followed by sputum(6.54%).Cefoxitin resistance was identified in 86.2% of Staphylococcus.No Staphylococcus strain resistant to vancomycin,linezolid and minocycline was detected.The extended spectrum β-lactamases(ESBLs) producing strains in gram-negative pathogenic bacteria were 35.90%.The drug resistant rates of the gram-negative bacilli to carbapenem and drugs containing enzyme inhibitor were low.The drug resistant rates of E.coli to current antibiotics were very high,but the drug resistant rates of P.aeruginosa,and K.pneumonia were low.CONCLUSION The most common site of infection is blood stream and the dominant pathogen is gram-negative bacteria in hematology department,and the infection rate of fungi is quite higher.Timely collection of specimens,better microbiological identification and appropriate susceptibility testing are essential for effective infection control and prevention of antibiotic resistance