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Effect of Emodin on HMGB1 Release from Endotoxin-stimulated Macrophages

Chen Guo-qian

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Abstract

Objective To study the effect of emodin on mRNA expression and extracellular release of high mobility group box 1(HMGB1)in endotoxin-stimulated macrophages.Methods The changes of HMGB1 and TNF-α levels in the culture medium and expression of HMGB1 mRNA were investigated after Emodin(5、20、50 μmol/L)was incubated with lipopolysaccharide-stimulated cultured mouse peritoneal macrophages.Results Emodin(50 μmol/L)markedly suppressed the release of HMGB1 and TNF-α,and expression of HMGB1 mRNA from lipopolysaccharide-stimulated macrophages(P﹤0.01).Conclusion Emodin confers inhibition onto extracellular release of HMGB1 and expression of HMGB1 mRNA from endotoxin-stimulated macrophages.

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Objective To study the effect of emodin on mRNA expression and extracellular release of high mobility group box 1(HMGB1)in endotoxin-stimulated macrophages.Methods The changes of HMGB1 and TNF-α levels in the culture medium and expression of HMGB1 mRNA were investigated after Emodin(5、20、50 μmol/L)was incubated with lipopolysaccharide-stimulated cultured mouse peritoneal macrophages.Results Emodin(50 μmol/L)markedly suppressed the release of HMGB1 and TNF-α,and expression of HMGB1 mRNA from lipopolysaccharide-stimulated macrophages(P﹤0.01).Conclusion Emodin confers inhibition onto extracellular release of HMGB1 and expression of HMGB1 mRNA from endotoxin-stimulated macrophages.

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Available abstract

Objective To study the effect of emodin on mRNA expression and extracellular release of high mobility group box 1(HMGB1)in endotoxin-stimulated macrophages.Methods The changes of HMGB1 and TNF-α levels in the culture medium and expression of HMGB1 mRNA were investigated after Emodin(5、20、50 μmol/L)was incubated with lipopolysaccharide-stimulated cultured mouse peritoneal macrophages.Results Emodin(50 μmol/L)markedly suppressed the release of HMGB1 and TNF-α,and expression of HMGB1 mRNA from lipopolysaccharide-stimulated macrophages(P﹤0.01).Conclusion Emodin confers inhibition onto extracellular release of HMGB1 and expression of HMGB1 mRNA from endotoxin-stimulated macrophages.

Key concepts: HMGB1, Emodin, Lipopolysaccharide, Extracellular, Messenger RNA, High-mobility group, Macrophage, Chemistry

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Effect of Emodin on HMGB1 Release from Endotoxin-stimulated Macrophages — Research Paper | ScholarLens