Effect of Fuzheng Huoxue Recipes on Liver Fibrosis Associated Serum Indicators and Hepatic Hydroxyproline in Liver Fibrosis Rats

Objective To investigate the effect of different Fuzheng Huoxue Recipes,Chinese herbal recipes with the actions of supporting healthy-Qi and activating blood-stasis,on serum indicators of liver fibrosis and hepatic hydroxyproline(Hyp) content in liver fibrosis rats.Methods Ninety SD rats were randomized in six groups.Liver fibrosis was established by using carbon tetrachloride(CCl4) plus olive oil treatment.The serum indicators of liver fibrosis and hepatic Hyp content were detected in rats after treatment with different Fuzheng Huoxue Recipes including Huoxue Jianpi Yiqi Recipe(with the actions of activating blood,strengthening spleen and invigorating Qi),Huoxue Ziyang Ganshen Recipe(with the actions of activating blood,nourishing liver and kidney),and Huoxue Wenbu Pishen Recipe(with the actions of activating blood,strengthening spleen and warming kidney).Results Compared with the model control group,the differences of liver fibrosis associated serum markers of laminin(LN),hyaluronic acid(HA),procollagen type Ⅲ(PⅢP) and collage type IV(IV-C) were significant in different Fuzheng Huoxue Recipes(P 0.01 or P 0.05).And Huoxue Jianpi Yiqi Recipe and Huoxue Ziyang Ganshen Recipe had the better effect.Meanwhile,the two recipes above decreased Hyp content of liver tissue obviously(P 0.05).Conclusion Different Fuzheng Huoxue Recipes can improve the serum markers of liver fibrosis and hepatic Hyp content in liver fibrosis rats,which may be contributed to their therapeutic mechanisms.