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2011•Jiangsu Medical JournalRequires access

Effects of matrine on proliferation and apoptosis in human breast cancer MCF-7 cells

Bai Mei-ling

Open publisher page 2 citations

Abstract

Objective To investigate the effects of matrine on proliferation and apoptosis in human breast cancer MCF-7 cells.Methods MCF-7 cells were cultured with matrine solution(group A) or culture solution(group B).The proliferation of MCF-7 cells was measured by MTT assay,and the change of cell morphology was observed.Bax and Bcl-2 expressions were detected by flow cytometry.Results Compared to group B,the proliferation of MCF-7 cells was significantly inhibited in group A in a time-and dose-dependent manner with increased apoptotic rate and Bax expression,but decreased Bcl-2 expression.Conclusion Matrine is able to significantly inhibit the growth of MCF-7 cells and induce apoptosis,which is related to an increase of Bax and decrease of Bcl-2.

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What this paper is about

Objective To investigate the effects of matrine on proliferation and apoptosis in human breast cancer MCF-7 cells.Methods MCF-7 cells were cultured with matrine solution(group A) or culture solution(group B).The proliferation of MCF-7 cells was measured by MTT assay,and the change of cell morphology was observed.Bax and Bcl-2 expressions were detected by flow cytometry.Results Compared to group B,the proliferation of MCF-7 cells was significantly inhibited in group A in a time-and dose-dependent manner with increased apoptotic rate and Bax expression,but decreased Bcl-2 expression.Conclusion Matrine is able to significantly inhibit the growth of MCF-7 cells and induce apoptosis,which is related to an increase of Bax and decrease of Bcl-2.

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Available abstract

Objective To investigate the effects of matrine on proliferation and apoptosis in human breast cancer MCF-7 cells.Methods MCF-7 cells were cultured with matrine solution(group A) or culture solution(group B).The proliferation of MCF-7 cells was measured by MTT assay,and the change of cell morphology was observed.Bax and Bcl-2 expressions were detected by flow cytometry.Results Compared to group B,the proliferation of MCF-7 cells was significantly inhibited in group A in a time-and dose-dependent manner with increased apoptotic rate and Bax expression,but decreased Bcl-2 expression.Conclusion Matrine is able to significantly inhibit the growth of MCF-7 cells and induce apoptosis,which is related to an increase of Bax and decrease of Bcl-2.

Key concepts: Matrine, MCF-7, Apoptosis, Flow cytometry, MTT assay, Cell growth, Human breast, Chemistry

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