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Study on the combining anti-hepatitis B virus in vitro

Song Xiu-guan

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Abstract

Objective Using transgenic HepG2,215 cell to study the combining anti-HBV effect of lamivudine,interferon α-2a and thymosin-α1. Methods Lamivudine,interferon α-2a,thymosin-α1 and combination of lamivudine with interferon (α-2a) and with thymosin-α1 were added into the cell culture liquid respectively.After routine culture,HBsAg and HBeAg (excreted) by the cells were detected using ELISA.Inhibition rates were calculated to evaluate the antiviral effect. (Results) Lamivudine has antiviral effects.Combination of lamivudine with interferon α-2a and with thymosin-α1 shows synergistic antiviral effects. Conclusions Lamivudine can play a direct anti-HBV role. The combination of lamivudine and immune modulator can enhance antiviral effects.

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Objective Using transgenic HepG2,215 cell to study the combining anti-HBV effect of lamivudine,interferon α-2a and thymosin-α1. Methods Lamivudine,interferon α-2a,thymosin-α1 and combination of lamivudine with interferon (α-2a) and with thymosin-α1 were added into the cell culture liquid respectively.After routine culture,HBsAg and HBeAg (excreted) by the cells were detected using ELISA.Inhibition rates were calculated to evaluate the antiviral effect. (Results) Lamivudine has antiviral effects.Combination of lamivudine with interferon α-2a and with thymosin-α1 shows synergistic antiviral effects. Conclusions Lamivudine can play a direct anti-HBV role. The combination of lamivudine and immune modulator can enhance antiviral effects.

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Available abstract

Objective Using transgenic HepG2,215 cell to study the combining anti-HBV effect of lamivudine,interferon α-2a and thymosin-α1. Methods Lamivudine,interferon α-2a,thymosin-α1 and combination of lamivudine with interferon (α-2a) and with thymosin-α1 were added into the cell culture liquid respectively.After routine culture,HBsAg and HBeAg (excreted) by the cells were detected using ELISA.Inhibition rates were calculated to evaluate the antiviral effect. (Results) Lamivudine has antiviral effects.Combination of lamivudine with interferon α-2a and with thymosin-α1 shows synergistic antiviral effects. Conclusions Lamivudine can play a direct anti-HBV role. The combination of lamivudine and immune modulator can enhance antiviral effects.

Key concepts: Lamivudine, HBeAg, HBsAg, Thymosin, Hepatitis B virus, Interferon, Virology, Alpha interferon

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