2012•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access
Effects of ginkgo biloba extract on liver FADD in acute liver failure
Yonghai Li
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Abstract
【Objective】To study the protection effect of ginkgo biloba extract(GBE) on TAA-induced acute liver failure(ALF).【Methods】46 rats were divided into five groups:The control group,the model group and GBE group.The model mice of acute liver failure were set up by giving intraperitoneal injection of TAA(300 mg/kg),the serum ALT and AST were determined,FADD were analyzed with RT-PCR.The protein expressions of FADD were analyzed with Western blot.【Results】The serum ALT and AST in mice in model group were increased significantly compared with control group.The serum ALT and AST in mice in GBE group were decreased significantly compared with model group.Compared with model group,the gene and protein expression of FADD was significantly up regulated in liver in GBE group.【Conclusion】GBE could protect hepatocytes from apoptosis and necrosis in acute liver injury by TAA in rat,and the mechanisms in part were associated with FADD.