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Effects of Cyclooxygenase-2 in Hepatocellular Carcinoma Invasion and Metastasis

Xia Gao

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Abstract

Objective:To study cyclooxygenase-2(COX-2)expression in hepatocellular carcinoma and the relationships between COX-2 and MMP-2, MMP-9. Methods: The expressions of COX-2, MMP-2 and MMP-9 were determined by immunohistochemical method in 43 hepatocellular carcinoma tissues, 6 hepatocirrhosis tissues and 10 normal controls. Results: COX-2 expression in hepatocellular carcinoma tissues was higher than those in cirrhosis tissues and normal. There was no significant difference of COX-2 among sex, age, tumor size, tumor capsule, presence of portal vein thrombosis, the level of -fetoprotein and histo-differentiation (P 0.05). COX-2 expression was correlated with MMP-2 and MMP-9 expressions (r=0.508, r = 0.368, P 0.01). MMP-2 expression was positively correlated to MMP-9 expression(r=0.472, P 0.01). Conclusion: COX-2 may stimulate the invasion and metastasis in hepatocellular carcinoma by increasing MMP-2 and MMP-9 expression.

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Objective:To study cyclooxygenase-2(COX-2)expression in hepatocellular carcinoma and the relationships between COX-2 and MMP-2, MMP-9. Methods: The expressions of COX-2, MMP-2 and MMP-9 were determined by immunohistochemical method in 43 hepatocellular carcinoma tissues, 6 hepatocirrhosis tissues and 10 normal controls. Results: COX-2 expression in hepatocellular carcinoma tissues was higher than those in cirrhosis tissues and normal. There was no significant difference of COX-2 among sex, age, tumor size, tumor capsule, presence of portal vein thrombosis, the level of -fetoprotein and histo-differentiation (P 0.05). COX-2 expression was correlated with MMP-2 and MMP-9 expressions (r=0.508, r = 0.368, P 0.01). MMP-2 expression was positively correlated to MMP-9 expression(r=0.472, P 0.01). Conclusion: COX-2 may stimulate the invasion and metastasis in hepatocellular carcinoma by increasing MMP-2 and MMP-9 expression.

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Available abstract

Objective:To study cyclooxygenase-2(COX-2)expression in hepatocellular carcinoma and the relationships between COX-2 and MMP-2, MMP-9. Methods: The expressions of COX-2, MMP-2 and MMP-9 were determined by immunohistochemical method in 43 hepatocellular carcinoma tissues, 6 hepatocirrhosis tissues and 10 normal controls. Results: COX-2 expression in hepatocellular carcinoma tissues was higher than those in cirrhosis tissues and normal. There was no significant difference of COX-2 among sex, age, tumor size, tumor capsule, presence of portal vein thrombosis, the level of -fetoprotein and histo-differentiation (P 0.05). COX-2 expression was correlated with MMP-2 and MMP-9 expressions (r=0.508, r = 0.368, P 0.01). MMP-2 expression was positively correlated to MMP-9 expression(r=0.472, P 0.01). Conclusion: COX-2 may stimulate the invasion and metastasis in hepatocellular carcinoma by increasing MMP-2 and MMP-9 expression.

Key concepts: Hepatocellular carcinoma, Immunohistochemistry, Cirrhosis, Metastasis, Matrix metalloproteinase, Pathology, Medicine, Portal vein thrombosis

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Effects of Cyclooxygenase-2 in Hepatocellular Carcinoma Invasion and Metastasis — Research Paper | ScholarLens