2009•Chinese Journal of Clinical Oncology and RehabilitationRequires access
Expression of COX-2 and MMP-2 in hepatocellular carcinoma and its correlation study
Liu Rui-wen
Open publisher page 0 citations
Abstract
Objective To investigate the expression of cyclooxygenase-2 and matrix metalloproteinase-2 in HCC and the relationship between the expression and the clinical pathological parameters.Method Expression of COX-2 and MMP-2 was detected by imuno-histochemical method.Results The COX-2 protein expression rate was 80.4% and 47.8%(P0.05) in the HCC tissues and paracancerous liver tissues respectively.The expression rate of COX-2 was correlated significantly with tumor size,vein invasion and TNM stage.The MMP-2 protein expression rate was 68.6% and 25.0%(P0.05) in the HCC tissues and paracancerous liver tissues respectively.The exression rate of MMP-2 was correlated significantly with vein invasion and TNM stage.A close correlation was showed between the expression of COX-2 and MMP-2(P0.01).Conclusions COX-2 and MMP-2 were over-expressed and significantly correlated in HCC tissues,which means that COX-2 and MMP-2 might be involved in the process of genesis and progression of HCC.