Evaluation of the long-term effects of LASIK correction for myopia in China

Objective To evaluate the long-term efficacy and safety of laser in situ keratomileusis (LASIK) correction for myopia in China.Methods A comprehensive literature search was performed using two Chinese databases and the PubMed database.A meta-analysis was performed based on the results.Results This research study included 2,465 eyes (1,338 patients) from 8 independent studies.The follow-up period was 2 to 7 years.Meta analysis showed the efficacies in low to moderate myopia surpass that in severe myopia.The pooled odds ratios (OR,for ≤-6.0 D vs -6.0 D of myopia) were 8.36 (95% CI:6.31～11.08).During 5 to 7 years postoperatively,all eyes had 20/40 or better UCVA and 88.8% had 20/20 or better in the ≤-6.0 D myopia group.Among patients with -6.0 D of myopia,87.7% had 20/40 or better UCVA and 51.0% had 20/20 or better UCVA.Among all patients,78.5% and 38.3% of eyes were within ±1.0 D of the attempted corrected in low to moderate myopia and severe myopia,respectively.During 5 to 7 years postoperatively,1.0% to 3.4% of eyes lost ≥2 lines of best spectacle-corrected visual acuity,3.1% to 28.6% of patients reported glare and halos at night,and 12.2% of patients reported dry eye syndrome.Conclusion LASIK surgery is effective and safe.The efficacies in low to moderate myopia are better than that in high myopia.