2003•Journal of North Sichuan Medical CollegeRequires access
Expression and significance of tumor suppressor gene PTEN in gastric carcinoma
Zhu Zhi
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Abstract
Objectives To investigate expression and significance of tumor suppressor gene PTEN in gastric carcinoma. Method Immunohistochemical method was used to detect the expression of PTEN gene in 54 cases of gastric carcinomas and 6 cases of normal gastric mucous membrance tissues.Results The positive rate of PTEN protein was 100% in normal gastric tissues, but 46.3% (25/54) in gastric carcinomas. most of them were weak positive.The results showed a statistical significance between normal gastric tissues and gastric carcinomas(p0.05). The positive rates of PTEN protein which were positive or negative lymph node metastasis of gastric carcinoma was 9.5%(2/21) and 69.7%(23/33) respectively.The difference was significant(p0.01).Conclusion Expression of PTEN protein in gastric carcinoma was different from that of normal Gastric tissues. Some gastric carcinoma tissues had weak or negative expression of PTEN protein. This study suggest that there was inactivation of tumor suppressor gene PTEN in gastric carcinoma and the inactivation of tumor suppressor gene PTEN is related to tumorigenesis of gastric carcinoma. Tumor suppressor gene PTEN is probably a new tumor suppressor gene which related to gastric carcinoma.