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2005•Journal of Medical Science Yanbian UniversityRequires access

The significance of p 16~(INK4A) in the diagnosis of cervical malignant neoplasm and it's precursors

Zhe Jin

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Abstract

OBJECTIVE To evaluate the early diagnostic value of p 16INK4A in cervical malignant neoplasm and it' s precursors. METHODS The immunohistochemistry method was used to determine the impress of p 16INK4A monoclonal antibody in 47 of invasive squamous cell carcinomas, 30 of cervical intraepithelial neoplasia(CIN), 20 of adenocarcino-mas, and 20 of non-neoplastic cervices. RESULTS p 16INK4A was specifically detected in 100 % of adenocarcinomas, 79 % of squamous cell carcinoma, and 97% of CIN. CONCLUSION p 16 INK4A overexpression was a useful marker for the early diagnosis of epithelial neoplasm and it's precursors of cervix uteri.

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OBJECTIVE To evaluate the early diagnostic value of p 16INK4A in cervical malignant neoplasm and it' s precursors. METHODS The immunohistochemistry method was used to determine the impress of p 16INK4A monoclonal antibody in 47 of invasive squamous cell carcinomas, 30 of cervical intraepithelial neoplasia(CIN), 20 of adenocarcino-mas, and 20 of non-neoplastic cervices. RESULTS p 16INK4A was specifically detected in 100 % of adenocarcinomas, 79 % of squamous cell carcinoma, and 97% of CIN. CONCLUSION p 16 INK4A overexpression was a useful marker for the early diagnosis of epithelial neoplasm and it's precursors of cervix uteri.

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Available abstract

OBJECTIVE To evaluate the early diagnostic value of p 16INK4A in cervical malignant neoplasm and it' s precursors. METHODS The immunohistochemistry method was used to determine the impress of p 16INK4A monoclonal antibody in 47 of invasive squamous cell carcinomas, 30 of cervical intraepithelial neoplasia(CIN), 20 of adenocarcino-mas, and 20 of non-neoplastic cervices. RESULTS p 16INK4A was specifically detected in 100 % of adenocarcinomas, 79 % of squamous cell carcinoma, and 97% of CIN. CONCLUSION p 16 INK4A overexpression was a useful marker for the early diagnosis of epithelial neoplasm and it's precursors of cervix uteri.

Key concepts: Neoplasm, Immunohistochemistry, Medicine, Pathology, Cervical intraepithelial neoplasia, Cervix, Basal cell, Cervical cancer

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