Expression of MTA1,MMP-9,TIMP-1 protein in breast cancer tissue

Aim:To detect metastasis associated gene 1(MTA1),matrix metalloproteinase 9(MMP-9) and tissue inhibitor of matrix metalloproteinase1(TIMP-1) protein in breast cancer and analysis the relationship between these proteins expression and pathobiology behavior.Methods:SP Immunohistochemical technique was used to detect the expression of MTA1,MMP-9,TIMP-1 proteins among 56 human breast cancer and 20 normal breast tissues.Results:The positive rates of MTA1,MMP-9 and TIMP-1 proteins were 69.6%,73.2% and 51.8% respectively,which were 7.1%,10.7% and 5.4% in normal breast tissues and there were significant differences(χ2=46.25,42.38 and 27.34,P0.05).The over expression of MTA1 or MMP-9 and the low expression of TIMP-1 prorein were related with degree of differentiation,clinical stage and lymph node metastasis(P0.05).In addition,there was relationship between MTA1 and MMP-9 in human breast cancer(χ2=8.515,P0.05).Conclusion:The united detection of MTA1,MMP-9 and TIMP-1 expression may predict the ability of invasion and metastasis of breast cancer.