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2006•The Journal of Clinical PsychiatryRequires access

A random and controlled study of quetiapine and chlorpromazine in patients with schizophrenia

MA Jing-sha

Open publisher page 2 citations

Abstract

Objective:To compare the effects and adverse events of quetiapine and chlorpromazine in the treatment of schizophrenia. Method:191 inpatients came from 4 mental health center were entered into the study by a random ,controlled and opening way. The effects were evaluated by positive and negative symptom scale(PANSS),and the side effects by treatment emergent symptom scale(TESS).At the same time,blood glucose and prolactin were examined. Results:No significant difference in the efficacy was found between quetiapine and chlorpromazine (P0.05).There were more adverse effects in chlorpromazine group than in quetiapine group,especially in extrapyramidal side effect (EPS) and in choline system. Conclusion:Quetiapine has similar efficacy to chlorpromazine,with slight side effects,so it can be as a better choice for the patients with schizophrenia.

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What this paper is about

Objective:To compare the effects and adverse events of quetiapine and chlorpromazine in the treatment of schizophrenia. Method:191 inpatients came from 4 mental health center were entered into the study by a random ,controlled and opening way. The effects were evaluated by positive and negative symptom scale(PANSS),and the side effects by treatment emergent symptom scale(TESS).At the same time,blood glucose and prolactin were examined. Results:No significant difference in the efficacy was found between quetiapine and chlorpromazine (P0.05).There were more adverse effects in chlorpromazine group than in quetiapine group,especially in extrapyramidal side effect (EPS) and in choline system. Conclusion:Quetiapine has similar efficacy to chlorpromazine,with slight side effects,so it can be as a better choice for the patients with schizophrenia.

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Available abstract

Objective:To compare the effects and adverse events of quetiapine and chlorpromazine in the treatment of schizophrenia. Method:191 inpatients came from 4 mental health center were entered into the study by a random ,controlled and opening way. The effects were evaluated by positive and negative symptom scale(PANSS),and the side effects by treatment emergent symptom scale(TESS).At the same time,blood glucose and prolactin were examined. Results:No significant difference in the efficacy was found between quetiapine and chlorpromazine (P0.05).There were more adverse effects in chlorpromazine group than in quetiapine group,especially in extrapyramidal side effect (EPS) and in choline system. Conclusion:Quetiapine has similar efficacy to chlorpromazine,with slight side effects,so it can be as a better choice for the patients with schizophrenia.

Key concepts: Quetiapine, Chlorpromazine, Schizophrenia (object-oriented programming), Extrapyramidal symptoms, Adverse effect, Psychiatry, Medicine, Side effect (computer science)

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