Dynamic Changes and Clinical Significance of Serum TNF-α and IL-6 in Severe Acute Pancreatitis

Objective To investigate the changes and clinical significance of serum TNF-α and IL-6 in severe acute pancreatitis(SAP).Methods The serum levels of TNF-α and IL-6 in 32 cases of SAP and 25 normal controls were determined by EL ISA.Results On admission,the serum TNF-α level of the SAP group(48.5±12.1pg/mL) was significantly higher than that of the control group(13.5±3.8pg/mL),while the serum IL-6 level of the SAP group(66.7±19.3pg/mL) showed no significant difference from that of the control group compared with the control group(42.3±14.2pg/mL).The serum IL-6 level of the SAP group(180.1±41.4pg/mL) was significantly higher than that of the control group on Day 7 after admission;the serum levels of TNF-α and IL-6 in the SAP group(29.5±9.5pg/mL) and(102.8±24.6pg/mL) were significantly higher than those of the control group but there was no significant difference between the SAP group and the control group on Day 14 after treatment.Conclusion The determination of the serum levels of TNF-α and IL-6 may be of great value for early diagnosis,judgment of severity and prognosis of severe acute pancreatitis.