Observation of the efficiacy in patients with overactive bladder switching from tolterodine to solifenacin treatment

Objective To evaluate prospectively the effect and security of solifenacin in the overactive bladder patients that were invalid to tolterodine.Methods 30 patients that matched OAB diagnosis were all females.They were treated with solifenacin(5mg,qd,4 weeks) for they were invalid to tolterodine(2mg,bid, 4 weeks),The outcomes were evaluated by patients' self-report,the free uroflometry parameters(maximum urine streaming rate(Qmax),average urine streaming rate(Qave),row urine quantity(VV) and the OAB symptoms scores(OABSS).The untoward effect were observed during the trail.Results All 30 patients completed the treatment for 4 weeks,14 patients(46.7%) felt available including 10 patients(33.3%) felt evident and would like to continue use it.The characters of uroflowmetry were improved,Qmax was raised from(14.4 ±2.3) ml/s to(19.8±3.9) ml/s,Qave was raised from(8.7±1.5)ml/s to(11.7±2.6) ml/s,and VV was raised from(164.4±27.2) ml to(226.0±35.1) ml(P0.05).The scores of general OABSS and Urgency reduced evidently(P 0.01),and the scores of day micturation and nocturna were reduced too(P0.05).The bad reaction incidence rate was low,4 patients(13.3%)felt thirsty,but can tolerate.No serious adverse reaction happened.Conclusion Among the patients that were not effective to tolterodine,Patients receiving solifenacin also had significant improvements in symptoms of OAB.Moreover patient's tolerance and the compliance is good.