Association of dyslipidemia and concomitant risk factors in patients of acute myocardial infarction

Objective To test whether there were statistical differences in lipid levels between groups with and without certain risk factor,and further to investigate the association of dyslipidemia and concomitant risk factors in patients of acute myocardial infarction(AMI).Methods 110 cases of acute myocardial infarction were collected from May 2009 to May 2010.Serum lipid parameters were assayed,such as total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL),lipoprotein(a),apolipoprotein A and apolipoprotein B.All patients were separately divided into four kinds of group according to different risk factors,Younger group and elder group,Male group and female group,Hypertension group and non-hypertension group,Normal fasting blood-glucose(FBG)group and impaired fasting blood-glucose group.Contrast analysis of serum lipid parameters were performed on each group independently.Results Group Younger contained 51 male and 22 female patients,but Group Elder contained 17 males and 20 females.Significant difference(P0.05)were observed in sex ratio between these two groups.Lipid parameters like TG(1.47±1.04)mmol/L vs.(1.05±0.41)mmol/L,LDL/HDL(2.69±0.92 vs.2.32±0.85)and TG/HDL(1.41±1.19 vs.0.93±0.45)were higher in Group Younger than those in Group Elder(P values0.05),whereas other lipid parameters including TC,HDL,LDL,TC/HDL,N-HDL,lipoprotein(a),apolipoprotein A and apolipoprotein B showing no difference(P values 0.05).The onset age of AMI was significantly earlier in Group Male than that in Group Female(63.18 ±15.04)mmol/L vs.(74.36±11.23)mmol/L,P0.01.TC(4.84±1.25)mmol/L vs.(4.41±0.94)mmol/L and HDL(1.28±0.36)mmol/L vs.(1.09±0.24)mmol/L were higher in Group Female than those in Group Male(P values 0.05),while the other lipid parameters had no statistical difference between the two groups(P values 0.05).58.18% of AMI patients were concomitant with high blood pressure.There weren't statistical differences in sex ratio and average age between Group Hypertension and Group Non-Hypertension,but TC(4.81±1.09)mmol/L vs.(4.25±0.99)mmol/L,LDL(3.00±0.89)mmol/L vs.(2.63±0.87)mmol/L,TG(1.47±1.10)mmol/L vs.(1.13±0.46)mmol/L and N-HDL(3.61±1.04)mmol/L vs.(3.13±0.94)mmol/L were significantly higher in Group Hypertension(P values 0.05).Comparing with Group Normal FBG,Group Impaired FBG had higher levels of TC(4.87±1.18)mmol/L vs.(4.38±0.97)mmol/L,TG(1.63±1.24)mmol/L vs.(1.12±0.50)mmol/L,TG/HDL(1.52±1.41 vs.1.07±0.61)and N-HDL(3.70±1.04)mmol/L vs.(3.22±0.98)mmol/L(P values 0.05),without statistical difference in either sex ratio or average age.Conclusions There were statistical differences in lipid parameters(i.e.TC,HDL,LDL,TG,total and cholesterol ratio)between groups with and without certain risk factor.Hypertension and impaired FBG increased bad and cholesterol ratio,subsequently contributing to atherosclerosis.