Expression of Vascular Endothelial Growth Factor in Cervical Cancer and Its Relationship with Lymph Node Metastasis

Objective To study the expression of vascular endothelial growth factor(VEGF)A,C,D and lymphatic endothelial cell marker Prox-1 in cervical cancer,analyze their relationship with the clinical stage of cervical cancer and lymphatic metastasis,and interactions among VEGF-C/VEGF-D/VEGFR-3 signaling pathways.Methods Reverse transcriptase-polymerase chain(RT-PCR)and real-time RT-PCR was performed to test VEGF-A,C,D,and Prox-1 expressions in 100 cervical cancer tissues and 20 normal cervical tissues.Results VEGF-A,D and Prox-1 expressions were significantly different in lymph node tissues with or without lymph node metastasis.VEGF-C expression in cancer tissue was lower than that in normal tissue.Conclusion VEGF-A,C,D play the important roles in the lymphatic metastasis and possibly from multiple aspects impact the cervical cancer development and metastasis.