Clinical application of HA, PT and PLT combination detection in patients with chronic hepatitis B liver cirrhosis

Objective To investigate hyaluronic acid(HA), prothrombin time(PT) and platelet count(PLT) combination detection in patients with chronic hepatitis B cirrhosis of the liver for clinical diagnostic value. Methods Selected cases were divided into 53 cases of chronic hepatitis B patients, 75 cases of patients with chronic hepatitis B cirrhosis of the liver, the healthy check-up of 40 cases(control group), each group of HA, PT and PLT index were retrospectively analyzed; The liver cirrhosis group was divided into A level of 42 cases, B + C level 33 cases according to the Child- Pugh standard. The liver cirrhosis group was divided into upper gastrointestinal bleeding and no bleeding group, comparing the differences of HA, PT and PLT between groups. Results The PT, HA of hepatitis b patients with cirrhosis were increased and PLT decrease significantly than the chronic hepatitis B group and healthy group; HA, PT and abnormal PLT level in patients with cirrhosis B + C were higher than the group of patients with liver cirrhosis A, the differences were statistically significant(P 0.05). It no obvious difference was found between the HA, the differences of PT and PLT were statistically significant(P 0.05) which upper gastrointestinal group compared with no bleeding. Conclusion PT, HA, and PLT in combination detection can response the liver damage degree and the illness weight, there has important reference value in diagnosis and treatment of cirrhosis of the liver.