Research progress on hepatitis C virus quasispecies and its clinical significance

Hepatitis C virus(HCV),with highly genetic variation,was characterized by the existence of a wide quasispecies distribution within a single infected individual.It was proved HCV quasispecies play an important role in the virus escaping from the host immunosurveillance and the resistance to antiviral therapy,which lead to the chronic virus infection and persistent pathogenicity.Here,we summarized the generation of HCV quasispecies,the research of quasispecies?characters within each gene of HCV genome,and its clinical significance.