Characteristics and Laboratory Diagnosis of Hepatitis B Virus Quasispecies

HBV exists in the form of quasispecies in hosts.The evolution of HBV quasispecies determines the patients′ clinical manifestation and antiviral efficacy,from the view of quasispecies to research the characteristic of HBV evolution and the relationship between quasispecies and drug resistance can predict antiviral efficacy,prevent resistance,develop new treatments and so on.HBV quasispecies laboratory diagnostic technique is directly related to the research progress,the techniques of high sensitivity and specificity will play an important role in HBV quasispecies research.