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2008•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Determination of Residual Solvents in 5-methoxytrytamine by Capillary Gas Chromatography

Xiao Bing

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Abstract

Aim To establish an assay method for the determination of four residual solvents in 5-methoxytrytamine by programmed-temperature capillary GC.Methods The residual solvents which are ethyl acetate,tetrahydrofuran,dichloromethane and toluene were quantitatively determined by capillary GC on DB-35MS column with N,N-dimethylformamide(DMF) as solvent media and FID as the detector.Four residual solvents were completely separated.Results There was a good linearity(r≥0.999).The detected limits in the sample were 0.5~4.0ng;the RSD of precision was less than 2%;the average recovery rate was within the range of 95.0%～105.0%.Conclusion The method is simple,sensitive and accurate and can be used for quality control of 5-methoxytrytamine.

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Aim To establish an assay method for the determination of four residual solvents in 5-methoxytrytamine by programmed-temperature capillary GC.Methods The residual solvents which are ethyl acetate,tetrahydrofuran,dichloromethane and toluene were quantitatively determined by capillary GC on DB-35MS column with N,N-dimethylformamide(DMF) as solvent media and FID as the detector.Four residual solvents were completely separated.Results There was a good linearity(r≥0.999).The detected limits in the sample were 0.5~4.0ng;the RSD of precision was less than 2%;the average recovery rate was within the range of 95.0%～105.0%.Conclusion The method is simple,sensitive and accurate and can be used for quality control of 5-methoxytrytamine.

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Available abstract

Aim To establish an assay method for the determination of four residual solvents in 5-methoxytrytamine by programmed-temperature capillary GC.Methods The residual solvents which are ethyl acetate,tetrahydrofuran,dichloromethane and toluene were quantitatively determined by capillary GC on DB-35MS column with N,N-dimethylformamide(DMF) as solvent media and FID as the detector.Four residual solvents were completely separated.Results There was a good linearity(r≥0.999).The detected limits in the sample were 0.5~4.0ng;the RSD of precision was less than 2%;the average recovery rate was within the range of 95.0%～105.0%.Conclusion The method is simple,sensitive and accurate and can be used for quality control of 5-methoxytrytamine.

Key concepts: Dichloromethane, Chromatography, Toluene, Tetrahydrofuran, Chemistry, Gas chromatography, Residual, Solvent

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