Effect of different dosage of nimodipine on cerebral vasospasm patients after subarachnoid hemorrhage

Objective To explore the optimal dosage of nimodipine on preventing and curing cerebral vasospasm after subarachnoid hemorrhage(SAH).Mehtods 60 patients with primarily SAH were treated with 4 defferent dosages of nimodipine(2,1,0.5,0.2 mg/h;SAH1,SAH2,SAH3,SAH4 group) respectively.At 1,3,7,10,14 d after SAH,the blood flow velocities(BFV) of middle cerebral artery(MCA) were monitored by transcranial Doppler(TCD).The endothelin-1(ET-1) and NO were observed.Results Compared with the SAH1 and SAH2 group,the level of ET-1 in plasma and CSF of SAH3 and SAH4 group increased significanthy,while the level of NO and Vm of MCA decreased.Conclusion 1 mg/h of nimodipine is the optimal dosage on preventing CVS.