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2000•Journal of Taishan Medical CollegeRequires access

Dynamic changes of endothelin-1 levels in plasma and brain tissue during acute cerebral vasospasm following subarachnoid hemorrhagein rats

Sun Bao

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Abstract

Objective: To investigate the possible roles of endothelin 1(ET1)in the development of acute cerebral vasospasm(CVS) and related brain ischemicdamage following subarachnoid hemorrhage(SAH). Methods: SAH models of Wistar rats were used and animals were divided into SAH group and sham operated group. Diameter of basilar artery(BA) was measured before and after operation. Dynamic changes of regional cerebral blood flow(rCBF), and ET1 concentrations in both intracranial plasma and brain tissue were observed within 24 hours after SAH. Results: Within 24 hours after induction of SAH, rCBF decreased rapidly and persistently while ET1 concentrations increased obviously. Spasm of BA occurred 30 minutes after SAH. Conclusion: Increase of ET1 concentrations in plasma and brain tissue plays an important important role in the development of acute CVS and related brain ischemic damage after SAH.

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Objective: To investigate the possible roles of endothelin 1(ET1)in the development of acute cerebral vasospasm(CVS) and related brain ischemicdamage following subarachnoid hemorrhage(SAH). Methods: SAH models of Wistar rats were used and animals were divided into SAH group and sham operated group. Diameter of basilar artery(BA) was measured before and after operation. Dynamic changes of regional cerebral blood flow(rCBF), and ET1 concentrations in both intracranial plasma and brain tissue were observed within 24 hours after SAH. Results: Within 24 hours after induction of SAH, rCBF decreased rapidly and persistently while ET1 concentrations increased obviously. Spasm of BA occurred 30 minutes after SAH. Conclusion: Increase of ET1 concentrations in plasma and brain tissue plays an important important role in the development of acute CVS and related brain ischemic damage after SAH.

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Available abstract

Objective: To investigate the possible roles of endothelin 1(ET1)in the development of acute cerebral vasospasm(CVS) and related brain ischemicdamage following subarachnoid hemorrhage(SAH). Methods: SAH models of Wistar rats were used and animals were divided into SAH group and sham operated group. Diameter of basilar artery(BA) was measured before and after operation. Dynamic changes of regional cerebral blood flow(rCBF), and ET1 concentrations in both intracranial plasma and brain tissue were observed within 24 hours after SAH. Results: Within 24 hours after induction of SAH, rCBF decreased rapidly and persistently while ET1 concentrations increased obviously. Spasm of BA occurred 30 minutes after SAH. Conclusion: Increase of ET1 concentrations in plasma and brain tissue plays an important important role in the development of acute CVS and related brain ischemic damage after SAH.

Key concepts: Subarachnoid hemorrhage, Cerebral vasospasm, Medicine, Vasospasm, Basilar artery, Endothelin 1, Endothelin receptor, Cerebral blood flow

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Dynamic changes of endothelin-1 levels in plasma and brain tissue during acute cerebral vasospasm following subarachnoid hemorrhagein rats — Research Paper | ScholarLens