2009•Guangdong nongye kexueOpen access
Antibacterial Activity of Combination of Ciprofloxacin and Colistin against Isolated E. coli from Pigs
Pan Yu-shan
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Abstract
The minimum inhibitory concentration(MIC) value of Ciprofloxacin and Colistin against E.coli isolated from pigs was determined by using liquid double micro-dilution method,and the fractional inhibitory concentration(FIC) index of the combination of above two drugs was determined by using micro-board method,which could provide a theoretical basis for the development of new compound formulations of Ciprofloxacin.The results showed that: the MIC value of Ciprofloxacin against E.coli was ≥ 32 μg/mL,the MIC value of Colistin against E.coli was ≥ 16 μg/mL;when Ciprofloxacin and Colistin were combined,the MIC value was ≤ 8 μg/mL and ≤ 4 μg/mL respectively;the FIC index of their combination ranged from 0.09375 to 0.125.When Ciprofloxacin and Colistin were combined,the MIC value of them could be reduced,which showed significant synergies.