The In-vitro Post-Antibiotic Effect of Colistin Sulfate on E.coli

The MIC and MBC of colistin on four strains of E.coli was determined by microdilution mothed as 0 2 0 8 mg/L and 0 8 1 6 mg/L.Four strains of E.coli were exposed to colistin sulfate for 2 h,the mean value of PAE of four strains of E.coli ranged from 1 062 h to 2 017 h.E.coli CMCC44103 was exposed to 64,32,16,8,4,2 MIC colistin for 2 h,the mean value of PAE of colistin at the concentrations of 64,32,16,8,4,2 MIC were 0 517,2 487,2 037,1 727,1 407 and 1 057 h respectively.PAE was positively correlative with the drug concentration.