Radiosensitive effect of sodium glycididazole on rabbit VX2 lung transplant tumor

Aim To evaluate the sensitive effect of sodium glycididazole on three dimensional conformal radiation therapy of rabbit VX2 lung transplant tumor model.Methods Twenty-four tumor-bearing rabbits were evenly and randomly assigned to 3 groups: radiotherapy alone group、CMNa plus radiation group and control group.18F-fluorodeoxyglucose(FDG)PET/CT was used to monitor the ratio(T/M) of SUVmax(maximum standardized uptake value)against 18F-FDG in lung tumor tissue and the lateral spine muscle tissue before and after treatment and the change of tumor volume.Immunohistochemical method was used to detect the expression of vascular endothelial growth factor in cancer organization.T/M percentage change(M%),tumor volume growth rate(V%) and VEGF assay rate(VEGF%)were analyzed.Results 24 h after treatment,both CMNa plus radiation group and radiotherapy alone group exhibited a decrease in T/M value.Specifically,the decrease rate of M% in CMNa plus radiation group(34.3±12.4)was significantly higher than radiotherapy alone group(17.6±13.3)(P0.05).Among the three groups,the lung tumor volume increased after treatment.Especially in CMNa plus radiation group,the V% and VEGF% were at minimum value,which also showed a significant difference compared with the other two groups(P0.05).VEGF% was positively associated with M% and V% in every group(r=0.847,0.745,P0.05).Conclusion CMNa can improve the sensitivity of three dimensional conformal radiotherapy in hypoxic cells of VX2 lung transplant tumor.CMNa combined with radiotherapy can significantly inhibit tumor angiogenesis compared with the radiotherapy alone group.