Preparation and quality control of glucosamine hollow suppository

Objective To prepare and establish quality control for the glucosamine hollow type suppository.Methods The hollow type suppository was prepared with semi-synthetic fatty acid esters of glycerol as ground substance.The content of glucosamine was determined by HPLC system with o-phthalaldehyde precolumn derivatization at the wavelength of 330 nm.Results The linear range of glucosamine was 1~50 mg·L-1(r=0.999 8),with an average recovery rate of 99.73%(RDS=0.85%).The hollow type suppository was up to the quality of content standard,and it released quickly.The hollow type suppository released 98.51% in vitro for 20 minutes.Conclusion This preparation is simple and feasible in technology and controllable in quality.Drug release rate of hollow type suppository is higher than the conventional type suppository.