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2009•Hebei Journal of Industrial Science and TechnologyRequires access

Preparation and quality control of metronidazole hollow suppository

Sha Zhou

Open publisher page 1 citations

Abstract

The hollow type suppository and the conventional type suppository were prepared with mixed fatty glyceride as the base;the content of metronidazole was determined by ultraviolet spectrophotometry.The dissolution rate of the metronidazole hollow suppository was comparable to that of the conventional type suppository.The linear range of metronidazole was 3～15 μg/mL(r=0.999 8),with an average recovery rate of 99.26%(RSD=0.85%).Drug release rate of hollow type suppository is higher than the conventional type suppository.

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What this paper is about

The hollow type suppository and the conventional type suppository were prepared with mixed fatty glyceride as the base;the content of metronidazole was determined by ultraviolet spectrophotometry.The dissolution rate of the metronidazole hollow suppository was comparable to that of the conventional type suppository.The linear range of metronidazole was 3～15 μg/mL(r=0.999 8),with an average recovery rate of 99.26%(RSD=0.85%).Drug release rate of hollow type suppository is higher than the conventional type suppository.

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Available abstract

The hollow type suppository and the conventional type suppository were prepared with mixed fatty glyceride as the base;the content of metronidazole was determined by ultraviolet spectrophotometry.The dissolution rate of the metronidazole hollow suppository was comparable to that of the conventional type suppository.The linear range of metronidazole was 3～15 μg/mL(r=0.999 8),with an average recovery rate of 99.26%(RSD=0.85%).Drug release rate of hollow type suppository is higher than the conventional type suppository.

Key concepts: Suppository, Metronidazole, Chromatography, Chemistry, Pharmacology, Medicine, Antibiotics, Biochemistry

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