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2013•Lishizhen Medicine and Materia Medica ResearchRequires access

Study of Purification of extraction for Alkaloids from Sophora Flavescens

Han Li

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Abstract

Objective To study the method for Purification of extraction for Alkaloids from Sophora Flavescens.Methods To use Alkaloids from Sophora Flavescens、matrine、Oxymatrine as index,the macroporous resin was chosen to purify the extraction and the optimized parameters were selected.Results The AB-8 macroporous resin was chosen.Optimum process: pH = 10.0;diameter to height ratio of 1: 3;eluted by 1.5 BV water,elution flow rate was 2 BV / h to washing impurities;then eluted by 6 BV 50% ethanol,elution flow rate was 2 BV / h to elution effective component.Conclusion This optimized technology was stable,feasible.Total matrine is improved by 10.3 times,matrine and oxymatrine content increased 8 times.

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Objective To study the method for Purification of extraction for Alkaloids from Sophora Flavescens.Methods To use Alkaloids from Sophora Flavescens、matrine、Oxymatrine as index,the macroporous resin was chosen to purify the extraction and the optimized parameters were selected.Results The AB-8 macroporous resin was chosen.Optimum process: pH = 10.0;diameter to height ratio of 1: 3;eluted by 1.5 BV water,elution flow rate was 2 BV / h to washing impurities;then eluted by 6 BV 50% ethanol,elution flow rate was 2 BV / h to elution effective component.Conclusion This optimized technology was stable,feasible.Total matrine is improved by 10.3 times,matrine and oxymatrine content increased 8 times.

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Available abstract

Objective To study the method for Purification of extraction for Alkaloids from Sophora Flavescens.Methods To use Alkaloids from Sophora Flavescens、matrine、Oxymatrine as index,the macroporous resin was chosen to purify the extraction and the optimized parameters were selected.Results The AB-8 macroporous resin was chosen.Optimum process: pH = 10.0;diameter to height ratio of 1: 3;eluted by 1.5 BV water,elution flow rate was 2 BV / h to washing impurities;then eluted by 6 BV 50% ethanol,elution flow rate was 2 BV / h to elution effective component.Conclusion This optimized technology was stable,feasible.Total matrine is improved by 10.3 times,matrine and oxymatrine content increased 8 times.

Key concepts: Sophora flavescens, Matrine, Oxymatrine, Elution, Chromatography, Sophora, Chemistry, Extraction (chemistry)

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