The Expression of Integrin β1, MMP9 and VEGF in Human Prostatic Cancer

Objective: To investigate the expression of integrin β1,atrixmetalloproteinase(MMP9),and vascular endothelial growth factor (VEGF) in Human Prostatic cancer and its relationship with invasion and metastasis of tumor, and to analyze the correlation among the expression of the 3 proteins. Methods: Immunohistochemical method was used to detect the expression of the 3 proteins in 15 cases of benign prostate hyperplasia and 39 cases of prostatic cancer. Results: In the benign prostate hyperplasia cases and prostatic cancer cases, the positive expression of integrin β1, MMP9 and VEGF were 80.00% and 46.15%, 33.33% and 82.05%, and 46.67% and 82.05% respectively. There were significant differences of the expression of the 3 proteins between benign prostate hyperplasia and prostatic cancer (P0.05, P0.01). The positive expression of all the tree correlated with clinical stages of the diseases (P0.05, P0.01), but no correlation with the pathological differentiation was found (P0.05 ). Negative correlation existed between expression of integrin β1 and that of VEGF, and a positive correlation existed between expression of MMP9 and that of VEGF in prostatic cancer tissue. Conclusions: The investigation results show that integrin β1, MMP9, and VEGF might be involved in the process of the infiltration and metastasis of prostatic cancer. The combined reference of expression of integrin β1, MMP9, and VEGF benefits the better inference on the biological behavior of of prostatic cancer and could be used as good indicators for the prognosis predication of the disease.