An Association Study of MMP- 9 and VEGF Protein Expression in Prostate Cancer

Objective: To explore the expression of matrix metallo proteinases- 9( MMP- 9) and vascular endothelial growth factor( VEGF) in prostatic cancer( PCA) and the relations between them. Methods: The expression of VEGF and MMP- 9 in 120 cases of prostate cancer and 120 case s of BPH were detected by immunohistochemistry,with the relationship of their expression with clinical characteristics of prostatic cancer further analyzed. Results: The positive rate of MMP- 9 and VEGF expression in 120 cases PCA is 85. 01 % and 83. 32 %,respectively,significantly different from that in BPH( P 0. 0 5). The expression of MMP- 9 and VEGF in prostate cancer was positively correlated with pathological grading and clinical staging of PCA. Conclusion: The over expression of MMP- 9 and VEGF in PCA is correlated to the generation and the development of the prostatic carcinoma,which can be taken as an index of the prognosis of PCA.