Clinical Research of Orbital Tumor with ~1H MR Spectroscopy

Objective:To study the MR spectroscopy(MRS) findings in orbital diseases,and to investigate the corresponding biochemical parameters and their value for diagnosis,especially for the differential diagnosis of benign and malignant orbital tumors.Methods:40 patients with solitary lesions and all of them underwent MRI and MRS examinations.Pathology diagnosis after surgery was obtained.There were benign tumor and tumor-like lesion(n=30),malignant tumor(n=10).Results:Changes of varied compounds within different orbital tumors were compared with that of normal control group.The NAA peak level within orbital tumors decreased by different degree when compared with the control group(P0.05),which decreased 52.5% in cavernous hemangioma.However,the NAA level of small cell malignant tumor and adenoid cystic carcinoma increased markedly.There were marked differences in of Cho,Ace and Lac levels between benign and malignant tumors,which were much higher in malignant tumors.The value of Cho/Cr was much higher in malignant tumors,yet the Cr peak value did not show obvious difference.Conclusion:The MRS of tumors was different from that of normal brain tissue,manifested as various characteristic changes on Lac and Ace.The MRS peak values were different between benign and malignant tumors,such as the increased peak value of Cho and Cr,especially the increase of Cho/Cr value.Additionally,the Lac and Ace values were much higher in malignant tumors,which might become one of the criteria for the differential diagnosis of neoplasm and other diseases.