The value of ~1H-MRS in the diagnosis of the soft tissue tumors

Objective:To investigate the proton magnetic resonance spectroscopy(1H-MRS) features of benign and malignant soft tissue tumors in human and to explore its feasibility and application value in the differential diagnosis of soft tissue tumors.Materials and Methods:Forty-four cases were included in the study and divided into three groups.There were 10 cases in nomal group,14 cases in benign tumor group and 20 casese in malignant tumor group.MRI and 1H-MRS were performed in all cases.The 1H-MRS features of all the 44 cases were analyzed.Cho/Cr and Lipid/Cr were calculated on workstation and a statistic test was done.We caculated the cell density of 30 soft tissue tumors and performed pearson correlation analysis between the cell density and Cho/Cr value.Results:The Cho/Cr value in the malignant tumor was larger than that in the benign tumor and normal muscle,but the Lipid/Cr value was smaller than that in the benign tumor and normal muscle.The differences of Cho/Cr value and Lipid/Cr value between malignant and benign soft tissue tumors were statistically significant(P0.01).In contrast to benign tumor group,1H-MRS revealed increased Cho,Lac and decreased Lipid and Glc peak in the 12 cases of malignant tumor.The average cell density was 152/FOV in the malignant tumor group and 57/FOV in the benign tumor group.The value of the cell density had a significant positive correlation with the Cho/Cr value in soft tissue tumors(r=0.891,P0.001).Conclusion:The benign and malignant soft tissue tumors in human showed great difference in 1HMRS.1H-MRS has high application value in the differential diagnosis of soft tissue tumors.