A comparative study of olanzapine and aripiprazole in treatment of schizophrenia

Objective: To compare the efficacy and safety of olanzapine and aripiprazole in the treatment of schizophrenia. Method:100 patients were randomly assigned to olanzapine group or aripiprazole group respectively for 8 weeks.The positive and negative symptom scale(PANSS) and clinical global impressions-severity of illness rating scale(CGI-SI) were used to measure the efficacy;the treatment emergent symptom scale(TESS) was used to measure side effects. Results:Marked improvement rate of olanzapine group was 76.0%,and aripiprazole group was 72.0%,the efficacy was similar in two groups(P0.05);side effects of olanzapine were drowsiness,increase of body weight and blood pressure,which were obviously more frequent than in aripiprazole(P0.01);the main side effects of aripiprazole were extrapyramidal side effects and insomnia or excitement,which were more frequent than those in olanzapine group(P0.01). Conclusion: Olanzapine had similar effects to aripiprazole in the treatment of schizophrenia.They have high safety.