Correlations between CT Perfusion Imaging and Microvessel Density in Gliomas

Objective To discuss the correlations between relative cerebral blood volume(rCBV) value of CT perfusion imaging and microvessel density(MVD),and to explore the value of rCBV for preoperative grading of gliomas.Methods Thirty cases of glioma patients(11 low grade and 19 high grade astrocytomas) underwent conventional CT and CT perfusion imaging examination before operation.The absolute and relative value of CBV were measured in the parenchyma part of glioma and were processed statistically.The mean MVD of the lesions were measured immunohistochemically in all the histologie specimens.The relationship between rCBV and MVD were analyzed.Results The rCBV value had significantly positive(r=0.562,P0.05) correlation with MVD.The mean values of rCBV in low and high grade gliomas were(2.31±0.28) and(4.69±1.65) respectively.The value of rCBV between the two groups showed significant differences.Conclusion The value of rCBV is in good agreement with MVD,and is valuable for preoperative grading of gliomas in clinical procedures.