Correlation between the relative cerebral blood volume and microvessel density in patients with gliomas

Objective To investigate the correlation between the CT perfusion imaging parameter relative cerebral blood volume ( rCBV) and microvessel density( MVD) ,and to explore the value of rCBV in the preoperative grading of gliomas. Methods Thirty patients with glioma including 11 low grade cases and 19 high grade cases were underwent CT perfusion imaging examination before operation,the rCBV were measured in the parenchyma part; the MVD of the histologie specimens were measured immunohistochemically after operation . The correlation between rCBV and MVD was analyzed. Results rCBV in the cases of low and high grade gliomas were 2. 31 ± 0. 28 and 4. 69 ± 1. 65 respectively( P 0. 05) ; while the MVD were 40. 12 ± 8. 52 and 68. 87 ± 10. 35,P 0. 05; the value of rCBV was significantly correlated with the MVD( r = 0. 562,P 0. 05) . Conclusion The value of rCBV is in good agreement with MVD,and is valuable in preoperative grading of gliomas in clinical procedures.