Expressions of p57~(kip2) and cyclin E in human cervix carcinoma and their correlations with clinicopathology and prognosis

AIM: To investigate the effects of tumor suppressor gene p57~(kip2) and cyclin E in the genesis and progression of human cervix carcinoma and their clinicopathological and prognosticsignificances. METHODS: The expressions of p57~(kip2) and cyclin E in tumor tissues of 48 patients with cervix carcinoma and 13 cases with cervical intraepithelial neoplasia(CIN) and 15 cases with normal cervical epithelium were detected by Poly-HRP immunohistochemical technique.RESULTS: The positive expression rate of p57~(kip2) in tumor tissues of cervix carcinoma was 21%,which was lower than those in normal cervical epithelial(93%) and CIN tissues(77%),and there were significant differences(P0.01).The positive expression rate of cyclin E in tumor(tissues) of cervix carcinoma was 77%,which was higher than that in normal cervical epithelial tissues(13%);the difference was also significant(P0.01).In the tumor tissues,there was a significant negative correlation between cyclin E and p57~(kip2) positiveexpressions(r=-0.597,P0.01).P57~(kip2) positive-(expression) was associated significantly with tumor cell differentiation and lesion size(P0.05,P0.05).Cyclin E positive(expression) was correlated significantly with tumor cell differentiation and lymph node metastasis(P0.01,P0.05).Kaplan-Meier estimation indicated that the survival might be related to p57~(kip2) and cyclin E positive expressions(P0.01,P0.01).CONCLUSION: The decreased expression or loss of p57~(kip2) and/or over-expression of cyclin E may play an important role in the genesis and progression of cervix carcinoma,and be associated with poor prognosis,which act as a negative feedback mechanism in cell cycle regulation of cervix carcinoma.