Compound Mutagenesis and Screening of High Productivity Strains of Lincomycin

Streptomyces lincolnensis 9502,the starting strain in the experiment,was treated with NTG and mutant 9502-7 was screened by efficient agar piece cultural method.The mutant showed lincomycin-producing ability 35.4% higher than the starting strain.Then by treating the spores of mutant 9502-7 with UV,a strain of 9502-7-12 was obtained,whose titer was increased 50% more than the strain 9502..