2003•Journal of Chemical Industry and EngineeringRequires access
Synthesis of 2-bromo-5-fluorobenzoic acid
Yuan Zhou
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Abstract
Under common air pressure, 2 bromo 5 fluorotoluene is oxidized by oxygen to synthesize 2 bromo 5 fluorobenzoic acid. Acetic acid is used as solvent; acetic cobalt, acetic manganese and bromide sodium are used as catalyst. Reaction temperature ranging 120～130℃, 2 bromo 5 fluorotoluene concentration ranging 16.8%～20.2% and the catalyst dosage ranging 2.5%～4% of 2 bromo 5 fluorotoluene, the product yield is high.