Clinical observation of three-dimensional conformal radiotherapy combined with XELOX program for local recurrence after surgery of esophageal cancer

Objective:To investigate the clinical efficacy of three-dimensional conformal radiotherapy combined with XELOX(oxaliplatin+capecitabine) program chemotherapy for local recurrence after esophagectomy of esophageal cancer.Methods:A total of 69 cases with local recurrence after esophagectomy were randomly divided into treatment and control groups.In treatment group,35 patients received concurrent three-dimensional conformal radiotherapy and XELOX program chemotherapy.In control group,34 patients received XELOX program chemotherapy.Results:There was no statistically significant difference in general information between treatment group and control group.Response rates(RR) of treatment group and control group were 85.7% and 61.8%,with statistically significant differences(X2=5.130,P=0.024).One-year survival rates of treatment group and control group were 65.7% vs.41.2%(X2=4176,P=0.041),and 2-year survival rates of two groups were 45.7% vs.20.6 %(X2=4.900,P=0.027),with statistically significant differences between two groups.There was no statistically significant difference in incidences of nausea,vomiting and leukopenia,anemia and thrombocytopenia between treatment group and control group(X2=0.206,P=0.650;X2=0.008,P=0.930;X2=0.174,P=0.676;X2=1.052,P=0.305).Conclusions:Three-dimensional conformal radiotherapy concurrent with XELOX program chemotherapy can improve recent efficacy and long-term survival of patients with local recurrence after esophagectomy of esophageal cancer and reduce the side reactions.