[Expression and significance of IGF-1R and VEGF in gastric carcinoma].

AIM: To analyze the expression of IGF-1R and VEGF in human gastric carcinoma, and evaluate the relationship between their expression and tumor's invasion and metastasis. METHODS: 56 cases with gastric carcinoma, 20 cases of atypical hyperplasia tissues of adjacent carcinoma and 28 normal gastric mucosa membrane tissues were examined for the expression of IGF-1R and VEGF by SABC immunohistochemistry. RESULTS: The positive rates of IGF-1R protein in gastric carcinoma tissues, atypical hyperplasia tissues of adjacent carcinoma and normal gastric mucosa membrane tissues are 87.50%, 55.00% and 17.86%, respectively, and the difference between any two groups was significant (P<0.01); the positive rates of IGF-1R protein in the tissues of metastasis and non-metastasis are 97.06% and 72.73%, respectively(P<0.05); the positive rates of IGF-1R protein in the gastric carcinoma tissues of invaded submucosa, muscular and outer layers are 66.67%, 92.59% and 100%, respectively (P<0.05). The positive rates of VEGF protein in gastric carcinoma tissues, atypical hyperplasia tissues of adjacent carcinoma and normal gastric mucosa are 69.64%, 45.00% and 25.00%, respectively, and the difference between any two groups is significant (P<0.05); the positive rates of VEGF protein in the tissues of metastasis and non-metastasis are 85.29% and 45.45%, respectively (P<0.01); the positive rates of VEGF protein in the gastric carcinoma tissues of invaded submucosa, muscular and outer layers are 40.00%, 74.07% and 85.71%, respectively (P<0.05). CONCLUSION: The results suggest that the expression of IGF-1R or VEGF may be related to the development, invasion and metastasis of gastric carcinoma.