2012•Xiandai shengwu yixue jinzhanRequires access

Clinical Observation on Tiotropium Treatment of Elderly Patients with Stable COPD

Yonghui Zhang

Abstract

Objective: To investigate the efficacy of tiotropium inhaler in elderly smokers with stable chronic obstructive pulmonary disease(COPD).Methods: 92 elderly patients with stable COPD were randomly divided into 2 groups with each of 46 cases.The observation group were treated with inhaled tiotropium 18 micrograms once daily,and the control group were treated with sustained-release theophylline 0.1 g orally every 12 hours.All patients might use salbutamol aerosol if needed,and followed up for 2 months.Lung function and quality of life improvement were compared before and after treatment.Results: In the observation group,St George score decreased significantly after treatment(P0.01),significantly lower than the control group(P0.01).FEV1/FVC,FEV1/Pred,FEV1 was significantly higher than those before treatment(P0.01).However,the control group showed no significant difference(P0.05).Conclusion: Inhaled tiotropium can significantly improve lung function and life quality of elderly smokers with stable COPD.

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Key concepts: Medicine, COPD, Tiotropium bromide, Salbutamol, Theophylline, Lung function, Quality of life (healthcare), Inhaler