Effect of Bisoprolol on Chronic Heart Failure

OBJECTIVE To observe the effect and safety of bisoprolol on chronic heart failure(CHF).METHODS The multi-center,randomized,open,parallel control clinical trial clinical trial was conducted.128 CHF patients(NYHA Ⅱ to Ⅳ,LVEF≤0.4,on routine therapy at least 14 d) were involved in the study.The patients without β-blocker were designed randomly into 2 groups with the treatment of bisoprolol and carvedilol,respectivley;In patients treated with β-blocker,β-blocker was reduced gradually till drug withdrawal.The study lasted 6 months including preliminary period,dose increasing period and dose maintaining period.Blood pressure,heart rate and heart function were evaluated for each follow-up and adverse events were recorded.RESULTS The LVEF was improved significantly after treatment,(11% for bisoprolol group,and 10% for carvedilol group,P0.01).The symptoms of chronic heart failure in both groups were improved,the cases of grade Ⅲ(NYHA class) were reduced from 33.3% to 9.5% in bisoprolol group,from 40.0% to 10.8% in carvedilol group,which showed statistical differences between before and after treatment(P0.01).No significant difference was found on adverse events between bisolorol group(38%)and carvedilol group(46%).CONCLUSION Bisoprolol is as safe and effective as carvedilolin after the long-term use for the chronic heart failuretreatment.