A Comparison of Therapeutic Effect and Safety of Bisoprolol and Carvedilol in Treatment of Chronic Congestive Heart Failure

OBJECTIVE:To compare the therapeutic effect and safety of Bisoprolol and Carvedilol in the treatment of chronic congestive heart failure(CHF).METHODS:40 patients with CHF,who had received conventional anti-HF therapy UCG determination of left ventricular ejection fraction(LVEF)40%,were randomized into two groups to be respectively treated with Bisoprolol and Carvedilol for a maintained period of 6mo after the dosages being gradually expanded to maximum. RESULTS:Both groups showed significant improvement in heart function,blood pressure and heart rate after treatment(P 0.01),with the Bisoprolol group having more obvious improvement in LVEF and heart rate than the Carvedilol group(P 0.05),and the Carvedilol group having more obvious improvement in LVEDV,LVESV,SP(systolic pressure)and DP(diastolic pressure) than the Bisoprolol group(P0.01).The occurrence rate of adverse reaction was 35% for the Bisoprolol group and 60% for the Carvedilol group,indicating a statistical difference(P0.01).There was no exit of enrollees due to adverse reaction.CONCLUSIONS:Bisoprolol and Carvedilol can both improve the heart function of patients with CHF,but there is a difference in the degree of improvement effected with the two β-adrenergic receptor blockers.