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2002•The Chinese Journal of Clinical PharmacologyRequires access

Patient-controlled Analgesia with Tramadol vs Morphine in Patients Undergoing Abdominal Gynecological Surgery

Ye Tie

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Abstract

OBJECTIVE: To value the analgesic effect and drug adverse reaction of PCA with tramadol compared with morphine. Methods 59 patients,scheduled for elective hysterectomy or hysteromyomectomy, were randomly divided into Group T and Group M. Two drugs administered IV via a patient-controlled analgesia for up to 24 h postoperative. RESULTS: Efficacy was assessed by comparing total pain relief (TOTPAR) and sum of pain intensity difference (SPID) over 24h. Statistically significant equivalence of tramadol and morphine was shown by TOTPAR values15.9±4.4 and 16.4±3.5 by SPID values 9.2±2.7 and 9.0±2.0 respectively ( PO.05). Tramadol caused fewer adverse events than morphine (16.7% and 26.7% of patients,respectively. CONCLUSION: The study suggests that tramadaol provides an alternative to morphine for the treatment of postoperative pain.

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OBJECTIVE: To value the analgesic effect and drug adverse reaction of PCA with tramadol compared with morphine. Methods 59 patients,scheduled for elective hysterectomy or hysteromyomectomy, were randomly divided into Group T and Group M. Two drugs administered IV via a patient-controlled analgesia for up to 24 h postoperative. RESULTS: Efficacy was assessed by comparing total pain relief (TOTPAR) and sum of pain intensity difference (SPID) over 24h. Statistically significant equivalence of tramadol and morphine was shown by TOTPAR values15.9±4.4 and 16.4±3.5 by SPID values 9.2±2.7 and 9.0±2.0 respectively ( PO.05). Tramadol caused fewer adverse events than morphine (16.7% and 26.7% of patients,respectively. CONCLUSION: The study suggests that tramadaol provides an alternative to morphine for the treatment of postoperative pain.

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Available abstract

OBJECTIVE: To value the analgesic effect and drug adverse reaction of PCA with tramadol compared with morphine. Methods 59 patients,scheduled for elective hysterectomy or hysteromyomectomy, were randomly divided into Group T and Group M. Two drugs administered IV via a patient-controlled analgesia for up to 24 h postoperative. RESULTS: Efficacy was assessed by comparing total pain relief (TOTPAR) and sum of pain intensity difference (SPID) over 24h. Statistically significant equivalence of tramadol and morphine was shown by TOTPAR values15.9±4.4 and 16.4±3.5 by SPID values 9.2±2.7 and 9.0±2.0 respectively ( PO.05). Tramadol caused fewer adverse events than morphine (16.7% and 26.7% of patients,respectively. CONCLUSION: The study suggests that tramadaol provides an alternative to morphine for the treatment of postoperative pain.

Key concepts: Tramadol, Medicine, Morphine, Analgesic, Anesthesia, Adverse effect, Hysterectomy, Surgery

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