Influence of Qisang Jiangtang Fang on Blood Glucose and Serum Lipoprotein Metabolism in Rats with Experimental Type 2 Diabetes

Objective: To study the influence of Qisang Jiangtang Fang(Q-S) on blood glucose,serum lipoprotein in type 2 diabetes(T2DM) rats.Method: T2DM model was induced with high sucrose-fat diet for 4weeks and streptozocin(STZ) ip for 40 mg·kg-1,rats were randomly divided into groups: model group,Q-S low dose(ig 180 mg·kg-1·d-1) and middle dose(ig 360 mg·kg-1·d-1) and high dose group(ig 540 mg·kg-1·d-1),rosiglitazone treatment group(ig 4 mg·kg-1·d-1).Blood glucose,serum lipoprotein,hemoglobin Alc(HbAlc),insulin(Ins) contents in rats were detected after 60 d of continuous medication.Result: Compared with normal group,HbAlc levels were significantly increased(P 0.01),total cholesterol(TCH),total triglyceride(TG),low density lipoprotein(LDL) were significantly increased(P 0.05),high density lipoprotein(HDL) decreased significantly(P 0.05) in model group.Q-S can reduce the levels of blood glucose,HbAlc,TG,TCH and LDL,improve the level of HDL and Ins,those were significant deviation compare dwith the model group(P 0.05),it was no significant difference with the rosiglitazone treatment group.Conclusion: Q-S can effectively reduce rat's blood glucose of T2DM,promote Ins secretion,improve t the disorder of lipid metabolism in diabetic rats,regulate serum lipoprotein.