Influence of Zishenqinggan formula on blood glucose and serum lipoprotein metabolism in rats with type 2 diabetes mellitus

Objective To investigate the influence of Zishenqinggan formula( ZSQG) on blood glucose and serum lipoprotein metabolism in rats with type 2 diabetes mellitus( T2DM). Methods Type 2 diabetes models were induced with high sucrose-fat diet for 4 weeks and streptozotocin( STZ)( ip 30 mg / kg),and then they were randomly divided into 5 groups: model group,low-dose ZSQG group [ig 250 mg /( kg·d) ],medium-dose ZSQG group [ig 500 mg /( kg·d) ], high-dose ZSQG group [ig 750 mg /( kg·d) ]and rosiglitazone treatment group [ig 4 mg /( kg·d) ]. Blood glucose,serum lipoprotein,HbA1cand insulin contents in rats were detected as well as oral glucose tolerance test( OGTT) after 30 d of continuous medication by ZSQG low and medium and high-dose treatment. Results Compared with the model group, ZSQG significantly reduced the levels of blood glucose,HbA1c,triglyceride( TG),total cholesterol( TC) and low density lipoprotein( LDL) and the elevated blood glucose levels of diabetic rats after 120 min of glucose load in OGTT( all P 0. 05),ZSQG also significantly increased the level of high density lipoprotein( HDL) and insulin,insulin sensitivity index( ISI)( all P 0. 05). Conclusion ZSQG can effectively reduce the blood glucose of rats with T2DM and improve the disorder of lipid metabolism.