Simultaneous Determination of 195 Pesticide Residues in Vegetables Using Solid Phase Dispersive Extraction-Gas Chromatography-Tandem Mass Spectrometry

Objective: To develop a method for the determination of 195 pesticide residues in vegetables using gas chromatography with tandem mass spectrometry(GC-MS-MS) under a selected reaction monitoring(SRM) mode. Methods: The target compounds were extracted from samples with ethyl acetate and the extract was cleaned up by off-line solid phase dispersive extraction technique. The analytes were quantified by an internal standard method. Results: In the linear range(0.01–1.00 mg/L), the correlation coefficient for each pesticide was higher than 0.99. The average recoveries at three spiked levels(10, 20 and 100 μg/kg) varied from 37.6% to 136.7% with relative standard deviations(RSDs) between 0.2% and 15.3%. The limits of quantification(LOQ)(signal/noise ratio = 10) were 1.9–25.5 μg/kg. Conclusion: The method is rapid, sensitive, accurate and high throughput, without matrix interference and suitable for the analysis of 195 pesticide residues in vegetables.